pentobarbital will minimize the extent or outcome of guanfacine by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Modify Therapy/Observe Carefully. Powerful or moderate CYP3A4 inducers drastically lessen guanfacine plasma concentrations and elimination 50 percent-lifestyle.

pentobarbital will reduce the extent or effect of disopyramide by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Slight/Importance Unknown.

pentobarbital will minimize the extent or outcome of tacrolimus by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Use Warning/Check.

This drug may enhance the metabolism of estradiol when administered concurrently; sufferers on oral contraceptives are getting to be pregnant when concurrently dealt with with antiepileptic drugs; suggest an alternate contraceptive technique to Girls taking this drug

Administer barbiturates with warning in individuals with hepatic problems and at lowered doses in the beginning; barbiturates should not be administered to clients showing the premonitory indications of hepatic coma

pentobarbital will decrease the level or outcome of darunavir by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Use Warning/Monitor.

Monoamine oxidase inhibitors (MAOI) may possibly inhibit barbiturate metabolism and extend barbiturate effects; check closely

pentobarbital will lessen the level or result of etravirine by influencing hepatic enzyme CYP2C9/10 metabolism. Use Caution/Keep track of.

pentobarbital will lessen the level or influence of ritonavir by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Use Warning/Monitor.

pentobarbital will reduce the get more info extent or influence of dexamethasone by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Use Warning/Watch.

Check Intently (1)pentobarbital will minimize the level or effect of fentanyl transdermal by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Modify Therapy/Observe Carefully. Coadministration of fentanyl with CYP3A4 inducers could lead on to a minimize in fentanyl plasma concentrations, not enough efficacy or, potentially, development of the withdrawal syndrome within a client who has made Actual physical dependence to fentanyl. Just after stopping a CYP3A4 inducer, as being the effects of the inducer drop, the fentanyl plasma focus will raise which could increase or prolong both of those the therapeutic and adverse effects.

pentobarbital will minimize the level or influence of eucalyptus by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Slight/Significance Not known.

pentobarbital will lessen the level or effect of lumacaftor/ivacaftor by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Contraindicated.

pentobarbital will lower the extent or influence of doxorubicin by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Warning/Keep track of.